{
  "id": 566889,
  "title": "CODON Clarification required, Please Help",
  "url": "/competitions/stanford-rna-3d-folding/discussion/566889",
  "author_name": "",
  "post_date": "2025-03-07T09:10:20.919151900Z",
  "votes": null,
  "comment_count": 2,
  "views": 0,
  "content": "<p>As what I reconfirmed from GOOGLE, 'In RNA, from a Protien to be made,  the start codon, typically AUG, signals the beginning of protein synthesis, while the stop codons, UAA, UAG, and UGA, signal the end of translation' .</p>\n<p>Hence I expect the sequence to start with AUG and end at UAA/UAG/UGA, and taking 3 gram approach none of the end codon shall appear in the middle.</p>\n<p>The sequence doesnt seem to ALWAYS begin with AUG Start Codon, and Not Always end at any of the Stop Codon UAA, UAG or UGA.<br>\nHowever, I see some sequence which on going via 3 gram approach found stop codon in the middle.</p>\n<p>Could someone please help to clarify the domain ?</p>",
  "messages": [
    {
      "id": "3143473",
      "postDate": "03/07/2025 09:10:20",
      "content": "<p>As what I reconfirmed from GOOGLE, 'In RNA, from a Protien to be made,  the start codon, typically AUG, signals the beginning of protein synthesis, while the stop codons, UAA, UAG, and UGA, signal the end of translation' .</p>\n<p>Hence I expect the sequence to start with AUG and end at UAA/UAG/UGA, and taking 3 gram approach none of the end codon shall appear in the middle.</p>\n<p>The sequence doesnt seem to ALWAYS begin with AUG Start Codon, and Not Always end at any of the Stop Codon UAA, UAG or UGA.<br>\nHowever, I see some sequence which on going via 3 gram approach found stop codon in the middle.</p>\n<p>Could someone please help to clarify the domain ?</p>",
      "rawMarkdown": "As what I reconfirmed from GOOGLE, 'In RNA, from a Protien to be made,  the start codon, typically AUG, signals the beginning of protein synthesis, while the stop codons, UAA, UAG, and UGA, signal the end of translation' .\n\nHence I expect the sequence to start with AUG and end at UAA/UAG/UGA, and taking 3 gram approach none of the end codon shall appear in the middle.\n\nThe sequence doesnt seem to ALWAYS begin with AUG Start Codon, and Not Always end at any of the Stop Codon UAA, UAG or UGA.\nHowever, I see some sequence which on going via 3 gram approach found stop codon in the middle.\n\n\n\nCould someone please help to clarify the domain ?",
      "votes": null
    },
    {
      "id": "3143947",
      "postDate": "03/07/2025 18:37:29",
      "content": "<p>an RNA sequence isn't always coding for a protein</p>",
      "rawMarkdown": "an RNA sequence isn't always coding for a protein",
      "votes": null
    },
    {
      "id": "3144035",
      "postDate": "03/07/2025 21:12:42",
      "content": "<p>Most RNA molecules in this competition, and possibly all of them, are of the non-coding type. That means they do not code for proteins, which removes the requirement for start and stop codons.</p>\n<p>Even coding RNAs, specifically mRNA molecules, do not necessarily have start and stop codons at their very ends. They often contain untranslated regions at both ends, which also are free from the requirement to have start and stop codons.</p>",
      "rawMarkdown": "Most RNA molecules in this competition, and possibly all of them, are of the non-coding type. That means they do not code for proteins, which removes the requirement for start and stop codons.\n\nEven coding RNAs, specifically mRNA molecules, do not necessarily have start and stop codons at their very ends. They often contain untranslated regions at both ends, which also are free from the requirement to have start and stop codons.",
      "votes": null
    }
  ],
  "comments": [
    {
      "id": 3143947,
      "author_name": "louisstefanuto",
      "author_url": "",
      "post_date": "03/07/2025 18:37:29",
      "content": "<p>an RNA sequence isn't always coding for a protein</p>",
      "votes": null,
      "replies": []
    },
    {
      "id": 3144035,
      "author_name": "tilii7",
      "author_url": "",
      "post_date": "03/07/2025 21:12:42",
      "content": "<p>Most RNA molecules in this competition, and possibly all of them, are of the non-coding type. That means they do not code for proteins, which removes the requirement for start and stop codons.</p>\n<p>Even coding RNAs, specifically mRNA molecules, do not necessarily have start and stop codons at their very ends. They often contain untranslated regions at both ends, which also are free from the requirement to have start and stop codons.</p>",
      "votes": null,
      "replies": []
    }
  ],
  "raw_markdown_by_id": {
    "3143473": "As what I reconfirmed from GOOGLE, 'In RNA, from a Protien to be made,  the start codon, typically AUG, signals the beginning of protein synthesis, while the stop codons, UAA, UAG, and UGA, signal the end of translation' .\n\nHence I expect the sequence to start with AUG and end at UAA/UAG/UGA, and taking 3 gram approach none of the end codon shall appear in the middle.\n\nThe sequence doesnt seem to ALWAYS begin with AUG Start Codon, and Not Always end at any of the Stop Codon UAA, UAG or UGA.\nHowever, I see some sequence which on going via 3 gram approach found stop codon in the middle.\n\n\n\nCould someone please help to clarify the domain ?",
    "3143947": "an RNA sequence isn't always coding for a protein",
    "3144035": "Most RNA molecules in this competition, and possibly all of them, are of the non-coding type. That means they do not code for proteins, which removes the requirement for start and stop codons.\n\nEven coding RNAs, specifically mRNA molecules, do not necessarily have start and stop codons at their very ends. They often contain untranslated regions at both ends, which also are free from the requirement to have start and stop codons."
  },
  "source": "meta"
}