\"Your goal: to create a model that predicts the structures of any RNA molecule and the resulting chemical mapping profile, which can be compared to data collected for each position in the RNA.\"
\nIs the goal to predict the component sequences of a new RNA molecule such as \"AGUCUC …\"?
", "messages": [ { "id": "2453956", "postDate": "09/24/2023 12:57:30", "content": "\"Your goal: to create a model that predicts the structures of any RNA molecule and the resulting chemical mapping profile, which can be compared to data collected for each position in the RNA.\"
\nIs the goal to predict the component sequences of a new RNA molecule such as \"AGUCUC …\"?
", "rawMarkdown": "*\"Your goal: to create a model that predicts the structures of any RNA molecule and the resulting chemical mapping profile, which can be compared to data collected for each position in the RNA.\"*\n\nIs the goal to predict the component sequences of a new RNA molecule such as \"AGUCUC ...\"?", "votes": null }, { "id": "2454147", "postDate": "09/24/2023 15:55:06", "content": "It may help to think about RNA sequence not in isolation, but rather what it does in the context of a molecule. Many think that RNA is single-stranded, because it is made as such. Yet for most non-coding RNAs - which is what we are dealing with here - there are going to be base-pairing patterns and significant regions where it is double-stranded. In simplest terms, the reactivity determines whether a given RNA base is paired with another or not. Using that information the goal is ultimately to determine the exact pairing partners for each base, which would enable us to deduce its global structure. So yes, the goal is to predict the reactivity for any given RNA sequence, but in a context. Using your example, RNA bases in AGUCUC will have different reactivity in different molecules.
", "rawMarkdown": "It may help to think about RNA sequence not in isolation, but rather what it does in the context of a molecule. Many think that RNA is single-stranded, because it is made as such. Yet for most non-coding RNAs - which is what we are dealing with here - there are going to be base-pairing patterns and significant regions where it is double-stranded. In simplest terms, the reactivity determines whether a given RNA base is paired with another or not. Using that information the goal is ultimately to determine the exact pairing partners for each base, which would enable us to deduce its global structure. So yes, the goal is to predict the reactivity for any given RNA sequence, but in a context. Using your example, RNA bases in AGUCUC will have different reactivity in different molecules.", "votes": null }, { "id": "2456387", "postDate": "09/26/2023 06:51:27", "content": "Hi, I think the main goal of the competition is to create a model predicting reactivities for given RNA sequences.
\nNext step will be when scientists will get unknown RNA, get reactivities with MaP experiments and use the reversed model to determine the RNA sequence.
", "rawMarkdown": "Hi, I think the main goal of the competition is to create a model predicting reactivities for given RNA sequences. \n\nNext step will be when scientists will get unknown RNA, get reactivities with MaP experiments and use the reversed model to determine the RNA sequence.", "votes": null } ], "comments": [ { "id": 2454147, "author_name": "tilii7", "author_url": "", "post_date": "09/24/2023 15:55:06", "content": "It may help to think about RNA sequence not in isolation, but rather what it does in the context of a molecule. Many think that RNA is single-stranded, because it is made as such. Yet for most non-coding RNAs - which is what we are dealing with here - there are going to be base-pairing patterns and significant regions where it is double-stranded. In simplest terms, the reactivity determines whether a given RNA base is paired with another or not. Using that information the goal is ultimately to determine the exact pairing partners for each base, which would enable us to deduce its global structure. So yes, the goal is to predict the reactivity for any given RNA sequence, but in a context. Using your example, RNA bases in AGUCUC will have different reactivity in different molecules.
", "votes": null, "replies": [] }, { "id": 2456387, "author_name": "alexg5", "author_url": "", "post_date": "09/26/2023 06:51:27", "content": "Hi, I think the main goal of the competition is to create a model predicting reactivities for given RNA sequences.
\nNext step will be when scientists will get unknown RNA, get reactivities with MaP experiments and use the reversed model to determine the RNA sequence.
", "votes": null, "replies": [] } ], "raw_markdown_by_id": { "2453956": "*\"Your goal: to create a model that predicts the structures of any RNA molecule and the resulting chemical mapping profile, which can be compared to data collected for each position in the RNA.\"*\n\nIs the goal to predict the component sequences of a new RNA molecule such as \"AGUCUC ...\"?", "2454147": "It may help to think about RNA sequence not in isolation, but rather what it does in the context of a molecule. Many think that RNA is single-stranded, because it is made as such. Yet for most non-coding RNAs - which is what we are dealing with here - there are going to be base-pairing patterns and significant regions where it is double-stranded. In simplest terms, the reactivity determines whether a given RNA base is paired with another or not. Using that information the goal is ultimately to determine the exact pairing partners for each base, which would enable us to deduce its global structure. So yes, the goal is to predict the reactivity for any given RNA sequence, but in a context. Using your example, RNA bases in AGUCUC will have different reactivity in different molecules.", "2456387": "Hi, I think the main goal of the competition is to create a model predicting reactivities for given RNA sequences. \n\nNext step will be when scientists will get unknown RNA, get reactivities with MaP experiments and use the reversed model to determine the RNA sequence." }, "source": "meta" }