{
  "id": 3913,
  "title": "Medicines impact on tremors",
  "url": "/competitions/predicting-parkinson-s-disease-progression-with-smartphone-data/discussion/3913",
  "author_name": "",
  "post_date": "2013-02-25T09:11:04.850Z",
  "votes": null,
  "comment_count": 9,
  "views": 4113,
  "content": "<p>Hi again,</p>\r\n<p>Does the medicines taken for Parkinson treatment impact on reducing the disease effects like tremors and diskenesia ?</p>\r\n<p>BTW can we have the medicines taken by each person on a different file format, like Excel ? The actual format (pdf) offers some problems in correctly identifying which medicines observations correspond to which person.</p>\r\n<p>Thanks.</p>",
  "messages": [
    {
      "id": "20803",
      "postDate": "02/25/2013 09:11:04",
      "content": "<p>Hi again,</p>\r\n<p>Does the medicines taken for Parkinson treatment impact on reducing the disease effects like tremors and diskenesia ?</p>\r\n<p>BTW can we have the medicines taken by each person on a different file format, like Excel ? The actual format (pdf) offers some problems in correctly identifying which medicines observations correspond to which person.</p>\r\n<p>Thanks.</p>",
      "rawMarkdown": "",
      "votes": null
    },
    {
      "id": "20817",
      "postDate": "02/25/2013 17:43:35",
      "content": "<p>Hey Alexandre, &nbsp;<span style=\"line-height:1.4em\">I can't speak to your first question, but the Excel file you requested is attached.</span></p>",
      "rawMarkdown": "",
      "votes": null
    },
    {
      "id": "20905",
      "postDate": "02/27/2013 01:09:39",
      "content": "<p>[quote=Alexandre Luís;20803]</p>\r\n<p>Hi again,</p>\r\n<p>Does the medicines taken for Parkinson treatment impact on reducing the disease effects like tremors and diskenesia ?</p>\r\n<p>BTW can we have the medicines taken by each person on a different file format, like Excel ? The actual format (pdf) offers some problems in correctly identifying which medicines observations correspond to which person.</p>\r\n<p>Thanks.</p>\r\n<p>[/quote]</p>\r\n<p>&nbsp;</p>\r\n<p>Hi Alexandre,&nbsp;</p>\r\n<p>yes, the medicines taken for Parkinson's should impact on (meaning improving) tremor, rigidity and bradykinesia (slowness of movements). However - and here it becomes complicated - excess of therapy might lead to dyskinesia. &nbsp;Dyskinesias are uncontrolled\r\n movements that have lower frequency than tremor and are often triggered by levodopa/carbidopa (therapy) when it reaches&nbsp;the highest plasma concentration.&nbsp;</p>\r\n<p>I hope this helps.&nbsp;</p>\r\n<p>Best,&nbsp;</p>\r\n<p>Maurizio</p>",
      "rawMarkdown": "",
      "votes": null
    },
    {
      "id": "20912",
      "postDate": "02/27/2013 03:21:47",
      "content": "<p>Hi again,</p>\r\n<p>&nbsp;</p>\r\n<p>Since there is an impact of levodopa in PD syntoms, is there a way of knowing the time of medications take for each patient ? This is a issue that is relevant to better approach DM techniques to the data given. Thanks.</p>",
      "rawMarkdown": "",
      "votes": null
    },
    {
      "id": "20921",
      "postDate": "02/27/2013 17:24:26",
      "content": "<p>Unfortuately we did not record the times people were taking medications.&nbsp; But this could also offer an opportunity in trying to identify such situations (when medications were taken, on/off periods associated with medications, etc).&nbsp; Sorry we don't have\r\n that level of detail for confirmation.</p>",
      "rawMarkdown": "",
      "votes": null
    },
    {
      "id": "20945",
      "postDate": "02/28/2013 10:50:36",
      "content": "<p>I appreciate there is no record of the timing of the medications.</p>\r\n<p>Most of the participants list their PD medications but&nbsp;<span style=\"line-height:1.4em\">Daisey/Daisy doesn't. Presumably there isn't any more info?</span></p>",
      "rawMarkdown": "",
      "votes": null
    },
    {
      "id": "20949",
      "postDate": "02/28/2013 14:06:51",
      "content": "<p>We can get the specific list of PD meds for Daisey/Daisy.&nbsp; I believe it is the usual Requip and Sinemet. Will follow-up to confirm.</p>",
      "rawMarkdown": "",
      "votes": null
    },
    {
      "id": "20950",
      "postDate": "02/28/2013 14:30:52",
      "content": "<p>Daisey/Daisy meds for PD are sinimet, azilect, and requip</p>",
      "rawMarkdown": "",
      "votes": null
    },
    {
      "id": "21473",
      "postDate": "03/20/2013 23:18:34",
      "content": "<p>If medication use is being taken into consideration, might also need to look at what additional medications are being taken that&nbsp; can impact/ control tremors.&nbsp;&nbsp; Some cardiac meds (metaprolol for example) can contribute to the control of essential tremors.&nbsp;&nbsp;\r\n &nbsp;&nbsp;</p>\r\n<p>&nbsp;</p>",
      "rawMarkdown": "",
      "votes": null
    },
    {
      "id": "21482",
      "postDate": "03/21/2013 01:27:28",
      "content": "<p>[quote=DValenti;21473]</p>\r\n<p>If medication use is being taken into consideration, might also need to look at what additional medications are being taken that&nbsp; can impact/ control tremors.&nbsp;&nbsp; Some cardiac meds (metaprolol for example) can contribute to the control of essential tremors.&nbsp;&nbsp;\r\n &nbsp;&nbsp;</p>\r\n<p>&nbsp;</p>\r\n<p>[/quote]</p>\r\n<p>This is true, but beta-blockers are ineffective for PD-related tremors (and in general for resting tremors). On the other hand, though, there are some anti-psychotic drugs that can increase rigidity (secondary causes of parkinsonism). Ideally getting all\r\n medications and their interactions would be amazing, however in this pilot study we focused only on PD medications.&nbsp;</p>",
      "rawMarkdown": "",
      "votes": null
    }
  ],
  "comments": [
    {
      "id": 20817,
      "author_name": "wcukierski",
      "author_url": "",
      "post_date": "02/25/2013 17:43:35",
      "content": "<p>Hey Alexandre, &nbsp;<span style=\"line-height:1.4em\">I can't speak to your first question, but the Excel file you requested is attached.</span></p>",
      "votes": null,
      "replies": []
    },
    {
      "id": 20905,
      "author_name": "mauriziofacheris",
      "author_url": "",
      "post_date": "02/27/2013 01:09:39",
      "content": "<p>[quote=Alexandre Luís;20803]</p>\r\n<p>Hi again,</p>\r\n<p>Does the medicines taken for Parkinson treatment impact on reducing the disease effects like tremors and diskenesia ?</p>\r\n<p>BTW can we have the medicines taken by each person on a different file format, like Excel ? The actual format (pdf) offers some problems in correctly identifying which medicines observations correspond to which person.</p>\r\n<p>Thanks.</p>\r\n<p>[/quote]</p>\r\n<p>&nbsp;</p>\r\n<p>Hi Alexandre,&nbsp;</p>\r\n<p>yes, the medicines taken for Parkinson's should impact on (meaning improving) tremor, rigidity and bradykinesia (slowness of movements). However - and here it becomes complicated - excess of therapy might lead to dyskinesia. &nbsp;Dyskinesias are uncontrolled\r\n movements that have lower frequency than tremor and are often triggered by levodopa/carbidopa (therapy) when it reaches&nbsp;the highest plasma concentration.&nbsp;</p>\r\n<p>I hope this helps.&nbsp;</p>\r\n<p>Best,&nbsp;</p>\r\n<p>Maurizio</p>",
      "votes": null,
      "replies": []
    },
    {
      "id": 20912,
      "author_name": "alfrlj",
      "author_url": "",
      "post_date": "02/27/2013 03:21:47",
      "content": "<p>Hi again,</p>\r\n<p>&nbsp;</p>\r\n<p>Since there is an impact of levodopa in PD syntoms, is there a way of knowing the time of medications take for each patient ? This is a issue that is relevant to better approach DM techniques to the data given. Thanks.</p>",
      "votes": null,
      "replies": []
    },
    {
      "id": 20921,
      "author_name": "dvannoni",
      "author_url": "",
      "post_date": "02/27/2013 17:24:26",
      "content": "<p>Unfortuately we did not record the times people were taking medications.&nbsp; But this could also offer an opportunity in trying to identify such situations (when medications were taken, on/off periods associated with medications, etc).&nbsp; Sorry we don't have\r\n that level of detail for confirmation.</p>",
      "votes": null,
      "replies": []
    },
    {
      "id": 20945,
      "author_name": "jamesteo0",
      "author_url": "",
      "post_date": "02/28/2013 10:50:36",
      "content": "<p>I appreciate there is no record of the timing of the medications.</p>\r\n<p>Most of the participants list their PD medications but&nbsp;<span style=\"line-height:1.4em\">Daisey/Daisy doesn't. Presumably there isn't any more info?</span></p>",
      "votes": null,
      "replies": []
    },
    {
      "id": 20949,
      "author_name": "dvannoni",
      "author_url": "",
      "post_date": "02/28/2013 14:06:51",
      "content": "<p>We can get the specific list of PD meds for Daisey/Daisy.&nbsp; I believe it is the usual Requip and Sinemet. Will follow-up to confirm.</p>",
      "votes": null,
      "replies": []
    },
    {
      "id": 20950,
      "author_name": "dvannoni",
      "author_url": "",
      "post_date": "02/28/2013 14:30:52",
      "content": "<p>Daisey/Daisy meds for PD are sinimet, azilect, and requip</p>",
      "votes": null,
      "replies": []
    },
    {
      "id": 21473,
      "author_name": "dvalenti",
      "author_url": "",
      "post_date": "03/20/2013 23:18:34",
      "content": "<p>If medication use is being taken into consideration, might also need to look at what additional medications are being taken that&nbsp; can impact/ control tremors.&nbsp;&nbsp; Some cardiac meds (metaprolol for example) can contribute to the control of essential tremors.&nbsp;&nbsp;\r\n &nbsp;&nbsp;</p>\r\n<p>&nbsp;</p>",
      "votes": null,
      "replies": []
    },
    {
      "id": 21482,
      "author_name": "mauriziofacheris",
      "author_url": "",
      "post_date": "03/21/2013 01:27:28",
      "content": "<p>[quote=DValenti;21473]</p>\r\n<p>If medication use is being taken into consideration, might also need to look at what additional medications are being taken that&nbsp; can impact/ control tremors.&nbsp;&nbsp; Some cardiac meds (metaprolol for example) can contribute to the control of essential tremors.&nbsp;&nbsp;\r\n &nbsp;&nbsp;</p>\r\n<p>&nbsp;</p>\r\n<p>[/quote]</p>\r\n<p>This is true, but beta-blockers are ineffective for PD-related tremors (and in general for resting tremors). On the other hand, though, there are some anti-psychotic drugs that can increase rigidity (secondary causes of parkinsonism). Ideally getting all\r\n medications and their interactions would be amazing, however in this pilot study we focused only on PD medications.&nbsp;</p>",
      "votes": null,
      "replies": []
    }
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