Hello, Kagglers!
\nThis is my first Kaggle discussion launch.
Thank you so much for holding this clinically important competition, really enjoying this opportunity to learn machine learning to contribute to medicine.
\nI have one question about patients' background.
\nAre some patients (not all) in train or test groups under treatment for pulmonary fibrosis?
From my understanding, pulmonary function test (ex. FVC) is a kind of highly-variable test and contains lots of noise because of its nature.
\nHowever, some patients seem to have gradually-increasing FVCs during some period.
\nI have no idea whether this is among responses to medicine or just variation without treatment.
Best regards.
", "messages": [ { "id": "989871", "postDate": "08/29/2020 06:58:23", "content": "Hello, Kagglers!
\nThis is my first Kaggle discussion launch.
Thank you so much for holding this clinically important competition, really enjoying this opportunity to learn machine learning to contribute to medicine.
\nI have one question about patients' background.
\nAre some patients (not all) in train or test groups under treatment for pulmonary fibrosis?
From my understanding, pulmonary function test (ex. FVC) is a kind of highly-variable test and contains lots of noise because of its nature.
\nHowever, some patients seem to have gradually-increasing FVCs during some period.
\nI have no idea whether this is among responses to medicine or just variation without treatment.
Best regards.
", "rawMarkdown": "Hello, Kagglers!\nThis is my first Kaggle discussion launch.\n\nThank you so much for holding this clinically important competition, really enjoying this opportunity to learn machine learning to contribute to medicine.\n\nI have one question about patients' background.\nAre some patients (not all) in train or test groups under treatment for pulmonary fibrosis?\n\nFrom my understanding, pulmonary function test (ex. FVC) is a kind of highly-variable test and contains lots of noise because of its nature.\nHowever, some patients seem to have gradually-increasing FVCs during some period.\nI have no idea whether this is among responses to medicine or just variation without treatment.\n\nBest regards.", "votes": null }, { "id": "991165", "postDate": "08/30/2020 07:29:54", "content": "@simonlfwalsh
\n@ahmedhshahin
\nI hope you may read this topic and answer the question if you can.
\nThank you.
Hi @drtausamaru , thanks for your question. I have read the topic and will get back with the answer soon!
", "rawMarkdown": "Hi @drtausamaru , thanks for your question. I have read the topic and will get back with the answer soon!", "votes": null }, { "id": "991475", "postDate": "08/30/2020 12:45:15", "content": "Thank you so much for your kind reply.
", "rawMarkdown": "Thank you so much for your kind reply.", "votes": null }, { "id": "991668", "postDate": "08/30/2020 15:14:03", "content": "I also think that this is important.
", "rawMarkdown": "I also think that this is important.", "votes": null }, { "id": "991985", "postDate": "08/30/2020 19:23:41", "content": "Good idea, I'll take it into account. On my side, this information is unavailable, but we can assume a hopothesis for this by decreasing FVC. By the way, is lower FVC better?
", "rawMarkdown": "Good idea, I'll take it into account. On my side, this information is unavailable, but we can assume a hopothesis for this by decreasing FVC. By the way, is lower FVC better?", "votes": null }, { "id": "992099", "postDate": "08/30/2020 23:20:03", "content": "Thank you.
\nI think, in general, lower FVC (percent) means deteriorated restrictive condition.
lower FVC is worse for a patient. Thus, if he or she is under a treatment, we should expect flatter decrease of FVC for such a patient.
", "rawMarkdown": "lower FVC is worse for a patient. Thus, if he or she is under a treatment, we should expect flatter decrease of FVC for such a patient.", "votes": null }, { "id": "993789", "postDate": "09/01/2020 06:27:28", "content": "I totally agree with you.
\nA few patients under treatment may improve their FVC with variation, but I guess mean FVC value of treatment group tends to decrease more gradually than control (placebo) group.
\nSo, this notion should be important in not only predicting the value in this competition but also applying the model to real clinical situation.
Hi All,
\nThese patients were not on antifibrotic therapy.
\nThanks,
\nSimon
", "rawMarkdown": "Hi All, \n\nThese patients were not on antifibrotic therapy. \n\nThanks, \n\nSimon", "votes": null }, { "id": "993930", "postDate": "09/01/2020 08:37:37", "content": "Thank you very much for the clarification.
", "rawMarkdown": "Thank you very much for the clarification.", "votes": null }, { "id": "994048", "postDate": "09/01/2020 10:30:22", "content": "FVC means forced vital capacity.
", "rawMarkdown": "FVC means forced vital capacity.", "votes": null }, { "id": "994059", "postDate": "09/01/2020 10:37:55", "content": "Thank you for the info.
", "rawMarkdown": "Thank you for the info.", "votes": null }, { "id": "994840", "postDate": "09/02/2020 02:11:13", "content": "@drtausamaru Thanks for sharing a nice topic. Now it has become clear that we don't have the treatment group. But I'm just curious about how many patients have FVC increased. Hope it's very few and doesn't have a huge impact on our prediction model…
", "rawMarkdown": "drtausamaru Thanks for sharing a nice topic. Now it has become clear that we don't have the treatment group. But I'm just curious about how many patients have FVC increased. Hope it's very few and doesn't have a huge impact on our prediction model...", "votes": null }, { "id": "994850", "postDate": "09/02/2020 02:34:26", "content": "Most patients have less FVC values in the last three visits compared with the beginning.
\nBut some patients (not few) seem to have V-shaped FVC curve although it finally decreases to some extent.
@simonlfwalsh
\n@ahmedhshahin
\nI hope you may read this topic and answer the question if you can.
\nThank you.
Hi @drtausamaru , thanks for your question. I have read the topic and will get back with the answer soon!
", "votes": null, "replies": [] }, { "id": 991475, "author_name": "drtausamaru", "author_url": "", "post_date": "08/30/2020 12:45:15", "content": "Thank you so much for your kind reply.
", "votes": null, "replies": [] } ] }, { "id": 991668, "author_name": "atamazian", "author_url": "", "post_date": "08/30/2020 15:14:03", "content": "I also think that this is important.
", "votes": null, "replies": [] }, { "id": 991985, "author_name": "koza4ukdmitrij", "author_url": "", "post_date": "08/30/2020 19:23:41", "content": "Good idea, I'll take it into account. On my side, this information is unavailable, but we can assume a hopothesis for this by decreasing FVC. By the way, is lower FVC better?
", "votes": null, "replies": [ { "id": 992099, "author_name": "drtausamaru", "author_url": "", "post_date": "08/30/2020 23:20:03", "content": "Thank you.
\nI think, in general, lower FVC (percent) means deteriorated restrictive condition.
lower FVC is worse for a patient. Thus, if he or she is under a treatment, we should expect flatter decrease of FVC for such a patient.
", "votes": null, "replies": [] }, { "id": 993789, "author_name": "drtausamaru", "author_url": "", "post_date": "09/01/2020 06:27:28", "content": "I totally agree with you.
\nA few patients under treatment may improve their FVC with variation, but I guess mean FVC value of treatment group tends to decrease more gradually than control (placebo) group.
\nSo, this notion should be important in not only predicting the value in this competition but also applying the model to real clinical situation.
FVC means forced vital capacity.
", "votes": null, "replies": [] } ] }, { "id": 993891, "author_name": "simonlfwalsh", "author_url": "", "post_date": "09/01/2020 07:56:54", "content": "Hi All,
\nThese patients were not on antifibrotic therapy.
\nThanks,
\nSimon
", "votes": null, "replies": [ { "id": 993930, "author_name": "drtausamaru", "author_url": "", "post_date": "09/01/2020 08:37:37", "content": "Thank you very much for the clarification.
", "votes": null, "replies": [] }, { "id": 994059, "author_name": "atamazian", "author_url": "", "post_date": "09/01/2020 10:37:55", "content": "Thank you for the info.
", "votes": null, "replies": [] } ] }, { "id": 994840, "author_name": "riow1983", "author_url": "", "post_date": "09/02/2020 02:11:13", "content": "@drtausamaru Thanks for sharing a nice topic. Now it has become clear that we don't have the treatment group. But I'm just curious about how many patients have FVC increased. Hope it's very few and doesn't have a huge impact on our prediction model…
", "votes": null, "replies": [ { "id": 994850, "author_name": "drtausamaru", "author_url": "", "post_date": "09/02/2020 02:34:26", "content": "Most patients have less FVC values in the last three visits compared with the beginning.
\nBut some patients (not few) seem to have V-shaped FVC curve although it finally decreases to some extent.