![\"\"](\"https://www.googleapis.com/download/storage/v1/b/kaggle-forum-message-attachments/o/inbox%2F15071851%2F02387d2e8c29796d9b68d026cd989b6e%2FScreenshot%202023-12-20%20at%2000.33.52.png?generation=1703026410527448&alt=media\")
We analyzed various gene clusters, including transcription factors, RNA splicing factors, and others, to understand their stability under different conditions. Notably, RNA splicing factors like BAT1, HNRPD, and others showed significantly less stability compared to groups like housekeeping genes. This observation raises intriguing questions: Is there a biological reason behind the heightened sensitivity of splicing factors to perturbations? Or could this be an artifact of our data or analysis methods?
\n\n
Special thanks to Alexander Chervov for his insightful notebook, which provided a foundation for this analysis. You can view his work here: Alexander Chervov's Notebook.
", "messages": [ { "id": "2567746", "postDate": "12/19/2023 22:49:56", "content": "We analyzed various gene clusters, including transcription factors, RNA splicing factors, and others, to understand their stability under different conditions. Notably, RNA splicing factors like BAT1, HNRPD, and others showed significantly less stability compared to groups like housekeeping genes. This observation raises intriguing questions: Is there a biological reason behind the heightened sensitivity of splicing factors to perturbations? Or could this be an artifact of our data or analysis methods?
\n\n
Special thanks to Alexander Chervov for his insightful notebook, which provided a foundation for this analysis. You can view his work here: Alexander Chervov's Notebook.
", "rawMarkdown": "We analyzed various gene clusters, including transcription factors, RNA splicing factors, and others, to understand their stability under different conditions. Notably, RNA splicing factors like BAT1, HNRPD, and others showed significantly less stability compared to groups like housekeeping genes. This observation raises intriguing questions: Is there a biological reason behind the heightened sensitivity of splicing factors to perturbations? Or could this be an artifact of our data or analysis methods?\n\n[**View My Notebook**](https://www.kaggle.com/code/nikolenkosergei/op2-eda-housekeeping-genes)\n\n\n\nSpecial thanks to Alexander Chervov for his insightful notebook, which provided a foundation for this analysis. You can view his work here: [Alexander Chervov's Notebook](https://www.kaggle.com/code/alexandervc/op2-eda-housekeeping-genes).", "votes": null }, { "id": "2568118", "postDate": "12/20/2023 09:09:09", "content": "NM_id(RefSeq_mRNA_curated) is a number 0-18211?
", "rawMarkdown": "NM_id(RefSeq_mRNA_curated) is a number 0-18211?", "votes": null }, { "id": "2568148", "postDate": "12/20/2023 09:38:24", "content": "The NM_id (RefSeq mRNA curated) typically does not correlate with its alphabetical order in a list. So, the numerical value of NM_id is unlikely to match its position in an alphabetically sorted sequence list. If you meant that
", "rawMarkdown": "The NM_id (RefSeq mRNA curated) typically does not correlate with its alphabetical order in a list. So, the numerical value of NM_id is unlikely to match its position in an alphabetically sorted sequence list. If you meant that", "votes": null }, { "id": "2568234", "postDate": "12/20/2023 10:42:26", "content": "It would be really interesting to stratify this by drug classes. I wonder if this has to do with intended targets of the drugs.
\nAlso, we will be doing a post-competition analysis starting next year. Would you in general be interested in contributing to something like this?
", "rawMarkdown": "It would be really interesting to stratify this by drug classes. I wonder if this has to do with intended targets of the drugs.\n\nAlso, we will be doing a post-competition analysis starting next year. Would you in general be interested in contributing to something like this?", "votes": null }, { "id": "2568266", "postDate": "12/20/2023 11:23:28", "content": "Can you clarify the meaning of the number of compounds in an image?
\n![\"\"](\"https://www.googleapis.com/download/storage/v1/b/kaggle-forum-message-attachments/o/inbox%2F16791068%2F5b6bf172206f194ae0145b20ebe5f236%2Fnihms917441f4.jpg?generation=1703071353818990&alt=media\")
https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5990023/bin/nihms917441f4.jpg
", "rawMarkdown": "Can you clarify the meaning of the number of compounds in an image?\n\n\n\nhttps://www.ncbi.nlm.nih.gov/pmc/articles/instance/5990023/bin/nihms917441f4.jpg", "votes": null }, { "id": "2568632", "postDate": "12/20/2023 17:54:01", "content": "Yes it sounds interesting
", "rawMarkdown": "Yes it sounds interesting", "votes": null } ], "comments": [ { "id": 2568118, "author_name": "", "author_url": "", "post_date": "12/20/2023 09:09:09", "content": "NM_id(RefSeq_mRNA_curated) is a number 0-18211?
", "votes": null, "replies": [ { "id": 2568148, "author_name": "nikolenkosergei", "author_url": "", "post_date": "12/20/2023 09:38:24", "content": "The NM_id (RefSeq mRNA curated) typically does not correlate with its alphabetical order in a list. So, the numerical value of NM_id is unlikely to match its position in an alphabetically sorted sequence list. If you meant that
", "votes": null, "replies": [] } ] }, { "id": 2568234, "author_name": "malteluecken", "author_url": "", "post_date": "12/20/2023 10:42:26", "content": "It would be really interesting to stratify this by drug classes. I wonder if this has to do with intended targets of the drugs.
\nAlso, we will be doing a post-competition analysis starting next year. Would you in general be interested in contributing to something like this?
", "votes": null, "replies": [ { "id": 2568632, "author_name": "nikolenkosergei", "author_url": "", "post_date": "12/20/2023 17:54:01", "content": "Yes it sounds interesting
", "votes": null, "replies": [] } ] }, { "id": 2568266, "author_name": "", "author_url": "", "post_date": "12/20/2023 11:23:28", "content": "Can you clarify the meaning of the number of compounds in an image?
\n
https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5990023/bin/nihms917441f4.jpg
", "votes": null, "replies": [] } ], "raw_markdown_by_id": { "2567746": "We analyzed various gene clusters, including transcription factors, RNA splicing factors, and others, to understand their stability under different conditions. Notably, RNA splicing factors like BAT1, HNRPD, and others showed significantly less stability compared to groups like housekeeping genes. This observation raises intriguing questions: Is there a biological reason behind the heightened sensitivity of splicing factors to perturbations? Or could this be an artifact of our data or analysis methods?\n\n[**View My Notebook**](https://www.kaggle.com/code/nikolenkosergei/op2-eda-housekeeping-genes)\n\n\n\nSpecial thanks to Alexander Chervov for his insightful notebook, which provided a foundation for this analysis. You can view his work here: [Alexander Chervov's Notebook](https://www.kaggle.com/code/alexandervc/op2-eda-housekeeping-genes).", "2568118": "NM_id(RefSeq_mRNA_curated) is a number 0-18211?", "2568148": "The NM_id (RefSeq mRNA curated) typically does not correlate with its alphabetical order in a list. So, the numerical value of NM_id is unlikely to match its position in an alphabetically sorted sequence list. If you meant that", "2568234": "It would be really interesting to stratify this by drug classes. I wonder if this has to do with intended targets of the drugs.\n\nAlso, we will be doing a post-competition analysis starting next year. Would you in general be interested in contributing to something like this?", "2568266": "Can you clarify the meaning of the number of compounds in an image?\n\n\n\nhttps://www.ncbi.nlm.nih.gov/pmc/articles/instance/5990023/bin/nihms917441f4.jpg", "2568632": "Yes it sounds interesting" }, "source": "meta" }