{
  "id": 442367,
  "title": "Could we have the access to the DE of the single cells calculated from the original single-cell RNA-seq?  ",
  "url": "/competitions/open-problems-single-cell-perturbations/discussion/442367",
  "author_name": "",
  "post_date": "2023-09-22T09:51:33.495551200Z",
  "votes": 1,
  "comment_count": 1,
  "views": 0,
  "content": "<p>Hi, Organising Team:</p>\n<p>I understand that you couldn't give the weight of the DE extract model to protect the test data from exposure. But it will be useful if you could give the DE of single cells calculated by the DE extract model.  </p>\n<p>So, could you also offer the DE of the single cells calculated from the original single-cell RNA-seq in addition to only the pseudobulk data? The access to the DE of the single cells will give us a much more data amount for any machine learning method. </p>\n<p>I will appreciate it if you could give the single cell DE data. But any reason or difficulty about the advice will also be understood. </p>\n<p>Thank you for any reply.</p>",
  "messages": [
    {
      "id": "2451079",
      "postDate": "09/22/2023 09:51:33",
      "content": "<p>Hi, Organising Team:</p>\n<p>I understand that you couldn't give the weight of the DE extract model to protect the test data from exposure. But it will be useful if you could give the DE of single cells calculated by the DE extract model.  </p>\n<p>So, could you also offer the DE of the single cells calculated from the original single-cell RNA-seq in addition to only the pseudobulk data? The access to the DE of the single cells will give us a much more data amount for any machine learning method. </p>\n<p>I will appreciate it if you could give the single cell DE data. But any reason or difficulty about the advice will also be understood. </p>\n<p>Thank you for any reply.</p>",
      "rawMarkdown": "Hi, Organising Team:\n\nI understand that you couldn't give the weight of the DE extract model to protect the test data from exposure. But it will be useful if you could give the DE of single cells calculated by the DE extract model.  \n\nSo, could you also offer the DE of the single cells calculated from the original single-cell RNA-seq in addition to only the pseudobulk data? The access to the DE of the single cells will give us a much more data amount for any machine learning method. \n\nI will appreciate it if you could give the single cell DE data. But any reason or difficulty about the advice will also be understood. \n\nThank you for any reply.",
      "votes": null
    },
    {
      "id": "2455707",
      "postDate": "09/25/2023 16:51:25",
      "content": "<p>Hi <a href=\"https://www.kaggle.com/mrsyxxx\" target=\"_blank\">@mrsyxxx</a>, there is no single-cell DE values. Think of the single-cell data as observations from a given experimental condition (cell type, perturbation) and the DE value as a summary statistic (e.g. T score) calculated per-feature between distributions for each condition.</p>",
      "rawMarkdown": "Hi @mrsyxxx, there is no single-cell DE values. Think of the single-cell data as observations from a given experimental condition (cell type, perturbation) and the DE value as a summary statistic (e.g. T score) calculated per-feature between distributions for each condition.",
      "votes": null
    }
  ],
  "comments": [
    {
      "id": 2455707,
      "author_name": "danielburkhardt",
      "author_url": "",
      "post_date": "09/25/2023 16:51:25",
      "content": "<p>Hi <a href=\"https://www.kaggle.com/mrsyxxx\" target=\"_blank\">@mrsyxxx</a>, there is no single-cell DE values. Think of the single-cell data as observations from a given experimental condition (cell type, perturbation) and the DE value as a summary statistic (e.g. T score) calculated per-feature between distributions for each condition.</p>",
      "votes": null,
      "replies": []
    }
  ],
  "raw_markdown_by_id": {
    "2451079": "Hi, Organising Team:\n\nI understand that you couldn't give the weight of the DE extract model to protect the test data from exposure. But it will be useful if you could give the DE of single cells calculated by the DE extract model.  \n\nSo, could you also offer the DE of the single cells calculated from the original single-cell RNA-seq in addition to only the pseudobulk data? The access to the DE of the single cells will give us a much more data amount for any machine learning method. \n\nI will appreciate it if you could give the single cell DE data. But any reason or difficulty about the advice will also be understood. \n\nThank you for any reply.",
    "2455707": "Hi @mrsyxxx, there is no single-cell DE values. Think of the single-cell data as observations from a given experimental condition (cell type, perturbation) and the DE value as a summary statistic (e.g. T score) calculated per-feature between distributions for each condition."
  },
  "source": "meta"
}