{
  "id": 441700,
  "title": "Genes direct targets of the drugs ",
  "url": "/competitions/open-problems-single-cell-perturbations/discussion/441700",
  "author_name": "",
  "post_date": "2023-09-19T19:10:43.363626400Z",
  "votes": 10,
  "comment_count": 1,
  "views": 0,
  "content": "<p>Direct targets of the drugs might be of some use. <br>\nOne can try to get them somewhere like<br>\n<a href=\"https://www.pharmgkb.org/\" target=\"_blank\">https://www.pharmgkb.org/</a>, or <a href=\"https://pubchem.ncbi.nlm.nih.gov/compound/2244\" target=\"_blank\">https://pubchem.ncbi.nlm.nih.gov/compound/2244</a> or R-package <a href=\"https://www.bioconductor.org/packages/release/bioc/html/drugTargetInteractions.html\" target=\"_blank\">https://www.bioconductor.org/packages/release/bioc/html/drugTargetInteractions.html</a><br>\n(thanks to Elena Sharova for links)</p>\n<p>Or: </p>\n<p>Here is info from chatGPT (so might not be fully correct).<br>\nRequest like </p>\n<blockquote>\n  <p>Can you give me direct targets for  'Tipifarnib', 'Imatinib', 'Topotecan', 'Clemastine' in python dictionary with keys - name of drug</p>\n</blockquote>\n<p>Chat GPT did not answer for the full list so I splitted list of drugs and asked several times. </p>\n<pre><code>drug_targets = {\n    : [],\n    : [],\n    : [],\n    : [, ],\n    : [, ],\n    : []\n    : [, ],\n    : [, ],\n    : [, ],\n    : [],\n    : [, ],\n    : [],\n    : []\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [, ],\n    : [, , ],\n    : [],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : []\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [, ],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [, ],\n    : [],\n    : [, , ],\n    : [],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : [, , ],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : [],\n    : [, ],\n    : [, , ],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [, , ],\n    : [, , , , ],\n    : [, , , ],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [, , ],\n    : [, , , , ],\n    : [, , , ],\n    : [],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [, , ],\n    : [, , ],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n}\n</code></pre>\n<p>Possible additions:</p>\n<p>(Crizotinib + ROS1, Vandetanib + RET, Cabozantinib + AXL, VEGFR2, FLT3, c-KIT, Ceritinib + ROS1, IGF-1R, FAK, ACK1/TNK2).</p>",
  "messages": [
    {
      "id": "2447011",
      "postDate": "09/19/2023 19:10:43",
      "content": "<p>Direct targets of the drugs might be of some use. <br>\nOne can try to get them somewhere like<br>\n<a href=\"https://www.pharmgkb.org/\" target=\"_blank\">https://www.pharmgkb.org/</a>, or <a href=\"https://pubchem.ncbi.nlm.nih.gov/compound/2244\" target=\"_blank\">https://pubchem.ncbi.nlm.nih.gov/compound/2244</a> or R-package <a href=\"https://www.bioconductor.org/packages/release/bioc/html/drugTargetInteractions.html\" target=\"_blank\">https://www.bioconductor.org/packages/release/bioc/html/drugTargetInteractions.html</a><br>\n(thanks to Elena Sharova for links)</p>\n<p>Or: </p>\n<p>Here is info from chatGPT (so might not be fully correct).<br>\nRequest like </p>\n<blockquote>\n  <p>Can you give me direct targets for  'Tipifarnib', 'Imatinib', 'Topotecan', 'Clemastine' in python dictionary with keys - name of drug</p>\n</blockquote>\n<p>Chat GPT did not answer for the full list so I splitted list of drugs and asked several times. </p>\n<pre><code>drug_targets = {\n    : [],\n    : [],\n    : [],\n    : [, ],\n    : [, ],\n    : []\n    : [, ],\n    : [, ],\n    : [, ],\n    : [],\n    : [, ],\n    : [],\n    : []\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [, ],\n    : [, , ],\n    : [],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : []\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [, ],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [, ],\n    : [],\n    : [, , ],\n    : [],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : [, , ],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : [],\n    : [, ],\n    : [, , ],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [, , ],\n    : [, , , , ],\n    : [, , , ],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [, , ],\n    : [, , , , ],\n    : [, , , ],\n    : [],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [, , ],\n    : [, , ],\n    : [],\n    : [, ],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n    : [],\n}\n</code></pre>\n<p>Possible additions:</p>\n<p>(Crizotinib + ROS1, Vandetanib + RET, Cabozantinib + AXL, VEGFR2, FLT3, c-KIT, Ceritinib + ROS1, IGF-1R, FAK, ACK1/TNK2).</p>",
      "rawMarkdown": "Direct targets of the drugs might be of some use. \nOne can try to get them somewhere like\nhttps://www.pharmgkb.org/, or https://pubchem.ncbi.nlm.nih.gov/compound/2244 or R-package https://www.bioconductor.org/packages/release/bioc/html/drugTargetInteractions.html\n(thanks to Elena Sharova for links)\n\nOr: \n\nHere is info from chatGPT (so might not be fully correct).\nRequest like \n>Can you give me direct targets for  'Tipifarnib', 'Imatinib', 'Topotecan', 'Clemastine' in python dictionary with keys - name of drug\n\n\nChat GPT did not answer for the full list so I splitted list of drugs and asked several times. \n\n```python\ndrug_targets = {\n    'Clotrimazole': ['CYP51A1'],\n    'Mometasone Furoate': ['NR3C1'],\n    'Idelalisib': ['PIK3CD'],\n    'Vandetanib': ['EGFR', 'FLT4'],\n    'Bosutinib': ['ABL1', 'SRC'],\n    'Ceritinib': ['ALK']\n    'Lamivudine': ['HBV reverse transcriptase', 'HIV reverse transcriptase'],\n    'Crizotinib': ['ALK', 'MET'],\n    'Cabozantinib': ['RET', 'MET'],\n    'Flutamide': ['AR'],\n    'Dasatinib': ['ABL1', 'SRC'],\n    'Selumetinib': ['MEK1'],\n    'Trametinib': ['MEK1']\n    'ABT-199 (GDC-0199)': ['BCL2'],\n    'Oxybenzone': [],\n    'Vorinostat': ['HDAC'],\n    'Raloxifene': ['ESR1'],\n    'Linagliptin': ['DPP4'],\n    'Lapatinib': ['EGFR', 'ERBB2'],\n    'Canertinib': ['EGFR', 'ERBB2', 'ERBB4'],\n    'Disulfiram': [],\n    'Vardenafil': ['PDE5A'],\n    'Palbociclib': ['CDK4', 'CDK6'],\n    'Ricolinostat': ['HDAC'],\n    'Dabrafenib': ['BRAF'],\n    'Proscillaridin A;Proscillaridin-A': []\n    'IN1451': [],\n    'Ixabepilone': ['TUBB2C'],\n    'CEP-18770 (Delanzomib)': [],\n    'RG7112': ['MDM2'],\n    'MK-5108': ['AURKA'],\n    'Resminostat': ['HDAC'],\n    'IMD-0354': [],\n    'Alvocidib': ['CDK7'],\n    'LY2090314': ['PIM1'],\n    'Methotrexate': ['DHFR'],\n    'LDN 193189': ['ALK2'],\n    'Tacalcitol': [],\n    'Colchicine': ['TUBA1A', 'TUBB'],\n    'R428': ['AURKA'],\n    'TL_HRAS26': ['HRAS'],\n    'BMS-387032': ['CDK2'],\n    'CGP 60474': ['CDK1'],\n    'TIE2 Kinase Inhibitor': ['TEK'],\n    'PD-0325901': ['MAP2K1'],\n    'Isoniazid': ['InhA', 'KatG'],\n    'GSK-1070916': ['Aurora B'],\n    'Masitinib': ['KIT', 'PDGFRA'],\n    'Saracatinib': ['SRC'],\n    'CC-401': [],\n    'Decitabine': ['DNMT1'],\n    'Ketoconazole': ['CYP3A4'],\n    'HYDROXYUREA': ['RRM1'],\n    'BAY 61-3606': ['SYK'],\n    'Navitoclax': ['BCL2', 'BCL2L1'],\n    'Porcn Inhibitor III': ['PORCN'],\n    'GW843682X': ['PIM1', 'PIM2', 'PIM3'],\n    'Prednisolone': ['NR3C1'],\n    'Tamatinib': ['PDGFRB'],\n    'Tosedostat': ['AICAR transformylase', 'AICAR transformylase/IMP cyclohydrolase'],\n    'GSK256066': ['FAK'],\n    'MGCD-265': ['MET'],\n    'AZD-8330': ['MAP2K5'],\n    'RN-486': ['KIT'],\n    'Amiodarone': ['Potassium channels'],\n    'Belinostat': ['HDAC'],\n    'RVX-208': [],\n    'GO-6976': ['PKC'],\n    'Scriptaid': ['HDAC'],\n    'HMN-214': ['FLT3'],\n    'SB525334': ['TGFBR1'],\n    'AVL-292': ['BTK'],\n    'BMS-777607': ['FAK'],\n    'AZD4547': ['FGFR'],\n    'Foretinib': ['MET', 'VEGFR'],\n    'Tivozanib': ['VEGFR'],\n    'Quizartinib': ['FLT3'],\n    'IKK Inhibitor VII': ['IKK'],\n    'UNII-BXU45ZH6LI': [],\n    'Chlorpheniramine': [],\n    'Tivantinib': ['MET'],\n    'CEP-37440': [],\n    'TPCA-1': ['IKK'],\n    'AZ628': ['BRAF'],\n    'OSI-930': ['KIT'],\n    'AZD3514': ['AR'],\n    'Vanoxerine': ['DAT', 'NET'],\n    'PF-03814735': ['FLT3'],\n    'MLN 2238': ['Proteasome'],\n    'Dovitinib': ['FGFR', 'VEGFR', 'PDGFR'],\n    'K-02288': ['BRAF'],\n    'Midostaurin': ['FLT3', 'KIT'],\n    'I-BET151': ['BRD4'],\n    'STK219801': ['FLT3'],\n    'PRT-062607': ['SYK'],\n    'AT 7867': ['AKT1', 'AKT2'],\n    'Sunitinib': ['VEGFR', 'PDGFR', 'KIT'],\n    'Penfluridol': ['Dopamine receptor D2'],\n    'BMS-536924': ['IGF1R'],\n    'Perhexiline': [],\n    'BI-D1870': ['PDK1'],\n    'FK 866': ['NAMPT'],\n    'Mubritinib (TAK 165)': ['EGFR', 'HER2'],\n    'Doxorubicin': ['Topoisomerase II'],\n    'Pomalidomide': ['Cereblon'],\n    'Colforsin': ['Adenylyl cyclase'],\n    'Phenylbutazone': [],\n    'Protriptyline': [],\n    'Buspirone': ['5-HT1A receptor'],\n    'Clomipramine': [],\n    'Alogliptin': ['DPP4'],\n    'Nefazodone': ['Serotonin receptor'],\n    'ABT737': ['BCL2', 'BCL-XL', 'BCL-W'],\n    'Dactolisib': ['PIK3CA', 'PIK3CB', 'PIK3CD', 'PIK3CG', 'MTOR'],\n    'Nilotinib': ['ABL1', 'KIT', 'PDGFRA', 'BCR-ABL'],\n    'Buspirone': ['5-HT1A receptor'],\n    'Clomipramine': [],\n    'Alogliptin': ['DPP4'],\n    'Nefazodone': ['Serotonin receptor'],\n    'ABT737': ['BCL2', 'BCL-XL', 'BCL-W'],\n    'Dactolisib': ['PIK3CA', 'PIK3CB', 'PIK3CD', 'PIK3CG', 'MTOR'],\n    'Nilotinib': ['ABL1', 'KIT', 'PDGFRA', 'BCR-ABL'],\n    'Defactinib': ['FAK'],\n    'PF-04691502': ['FAK'],\n    'GLPG0634': ['JAK1', 'JAK2'],\n    'Sgc-cbp30': ['BRD4'],\n    'BX 912': ['PDK1'],\n    'SCH-58261': ['Adenosine receptor'],\n    'Ruxolitinib': ['JAK1', 'JAK2'],\n    'BAY 87-2243': [],\n    'O-Demethylated Adapalene': [],\n    'YK 4-279': [],\n    'Ganetespib (STA-9090)': [],\n    'SLx-2119': [],\n    'Oprozomib (ONX 0912)': ['Proteasome'],\n    'Desloratadine': ['Histamine receptor'],\n    'Pitavastatin Calcium': ['HMGCR'],\n    'TR-14035': [],\n    'AT13387': ['HSP90'],\n    'CHIR-99021': [],\n    'RG7090': ['ALK'],\n    'AMD-070 (hydrochloride)': [],\n    'BMS-265246': [],\n    'Tipifarnib': ['HRAS', 'KRAS', 'NRAS'],\n    'Imatinib': ['ABL1', 'KIT', 'PDGFRA'],\n    'Topotecan': ['TOP1'],\n    'Clemastine': ['H1F0', 'H1FX'],\n    '5-(9-Isopropyl-8-methyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine': [],\n    'CGM-097': [],\n    'TGX 221': ['PIK3CA'],\n    'Azacitidine': ['DNMT1'],\n    'Atorvastatin': ['HMGCR'],\n    'Riociguat': ['Guanylate cyclase'],\n}\n\n```\n\nPossible additions:\n\n (Crizotinib + ROS1, Vandetanib + RET, Cabozantinib + AXL, VEGFR2, FLT3, c-KIT, Ceritinib + ROS1, IGF-1R, FAK, ACK1/TNK2).",
      "votes": null
    },
    {
      "id": "2449997",
      "postDate": "09/21/2023 15:00:23",
      "content": "<p>i think that these databases should give API access to get the targets directly Python (or other languages). haven't checked though </p>",
      "rawMarkdown": "i think that these databases should give API access to get the targets directly Python (or other languages). haven't checked though",
      "votes": null
    }
  ],
  "comments": [
    {
      "id": 2449997,
      "author_name": "jalilnourisa",
      "author_url": "",
      "post_date": "09/21/2023 15:00:23",
      "content": "<p>i think that these databases should give API access to get the targets directly Python (or other languages). haven't checked though </p>",
      "votes": null,
      "replies": []
    }
  ],
  "raw_markdown_by_id": {
    "2447011": "Direct targets of the drugs might be of some use. \nOne can try to get them somewhere like\nhttps://www.pharmgkb.org/, or https://pubchem.ncbi.nlm.nih.gov/compound/2244 or R-package https://www.bioconductor.org/packages/release/bioc/html/drugTargetInteractions.html\n(thanks to Elena Sharova for links)\n\nOr: \n\nHere is info from chatGPT (so might not be fully correct).\nRequest like \n>Can you give me direct targets for  'Tipifarnib', 'Imatinib', 'Topotecan', 'Clemastine' in python dictionary with keys - name of drug\n\n\nChat GPT did not answer for the full list so I splitted list of drugs and asked several times. \n\n```python\ndrug_targets = {\n    'Clotrimazole': ['CYP51A1'],\n    'Mometasone Furoate': ['NR3C1'],\n    'Idelalisib': ['PIK3CD'],\n    'Vandetanib': ['EGFR', 'FLT4'],\n    'Bosutinib': ['ABL1', 'SRC'],\n    'Ceritinib': ['ALK']\n    'Lamivudine': ['HBV reverse transcriptase', 'HIV reverse transcriptase'],\n    'Crizotinib': ['ALK', 'MET'],\n    'Cabozantinib': ['RET', 'MET'],\n    'Flutamide': ['AR'],\n    'Dasatinib': ['ABL1', 'SRC'],\n    'Selumetinib': ['MEK1'],\n    'Trametinib': ['MEK1']\n    'ABT-199 (GDC-0199)': ['BCL2'],\n    'Oxybenzone': [],\n    'Vorinostat': ['HDAC'],\n    'Raloxifene': ['ESR1'],\n    'Linagliptin': ['DPP4'],\n    'Lapatinib': ['EGFR', 'ERBB2'],\n    'Canertinib': ['EGFR', 'ERBB2', 'ERBB4'],\n    'Disulfiram': [],\n    'Vardenafil': ['PDE5A'],\n    'Palbociclib': ['CDK4', 'CDK6'],\n    'Ricolinostat': ['HDAC'],\n    'Dabrafenib': ['BRAF'],\n    'Proscillaridin A;Proscillaridin-A': []\n    'IN1451': [],\n    'Ixabepilone': ['TUBB2C'],\n    'CEP-18770 (Delanzomib)': [],\n    'RG7112': ['MDM2'],\n    'MK-5108': ['AURKA'],\n    'Resminostat': ['HDAC'],\n    'IMD-0354': [],\n    'Alvocidib': ['CDK7'],\n    'LY2090314': ['PIM1'],\n    'Methotrexate': ['DHFR'],\n    'LDN 193189': ['ALK2'],\n    'Tacalcitol': [],\n    'Colchicine': ['TUBA1A', 'TUBB'],\n    'R428': ['AURKA'],\n    'TL_HRAS26': ['HRAS'],\n    'BMS-387032': ['CDK2'],\n    'CGP 60474': ['CDK1'],\n    'TIE2 Kinase Inhibitor': ['TEK'],\n    'PD-0325901': ['MAP2K1'],\n    'Isoniazid': ['InhA', 'KatG'],\n    'GSK-1070916': ['Aurora B'],\n    'Masitinib': ['KIT', 'PDGFRA'],\n    'Saracatinib': ['SRC'],\n    'CC-401': [],\n    'Decitabine': ['DNMT1'],\n    'Ketoconazole': ['CYP3A4'],\n    'HYDROXYUREA': ['RRM1'],\n    'BAY 61-3606': ['SYK'],\n    'Navitoclax': ['BCL2', 'BCL2L1'],\n    'Porcn Inhibitor III': ['PORCN'],\n    'GW843682X': ['PIM1', 'PIM2', 'PIM3'],\n    'Prednisolone': ['NR3C1'],\n    'Tamatinib': ['PDGFRB'],\n    'Tosedostat': ['AICAR transformylase', 'AICAR transformylase/IMP cyclohydrolase'],\n    'GSK256066': ['FAK'],\n    'MGCD-265': ['MET'],\n    'AZD-8330': ['MAP2K5'],\n    'RN-486': ['KIT'],\n    'Amiodarone': ['Potassium channels'],\n    'Belinostat': ['HDAC'],\n    'RVX-208': [],\n    'GO-6976': ['PKC'],\n    'Scriptaid': ['HDAC'],\n    'HMN-214': ['FLT3'],\n    'SB525334': ['TGFBR1'],\n    'AVL-292': ['BTK'],\n    'BMS-777607': ['FAK'],\n    'AZD4547': ['FGFR'],\n    'Foretinib': ['MET', 'VEGFR'],\n    'Tivozanib': ['VEGFR'],\n    'Quizartinib': ['FLT3'],\n    'IKK Inhibitor VII': ['IKK'],\n    'UNII-BXU45ZH6LI': [],\n    'Chlorpheniramine': [],\n    'Tivantinib': ['MET'],\n    'CEP-37440': [],\n    'TPCA-1': ['IKK'],\n    'AZ628': ['BRAF'],\n    'OSI-930': ['KIT'],\n    'AZD3514': ['AR'],\n    'Vanoxerine': ['DAT', 'NET'],\n    'PF-03814735': ['FLT3'],\n    'MLN 2238': ['Proteasome'],\n    'Dovitinib': ['FGFR', 'VEGFR', 'PDGFR'],\n    'K-02288': ['BRAF'],\n    'Midostaurin': ['FLT3', 'KIT'],\n    'I-BET151': ['BRD4'],\n    'STK219801': ['FLT3'],\n    'PRT-062607': ['SYK'],\n    'AT 7867': ['AKT1', 'AKT2'],\n    'Sunitinib': ['VEGFR', 'PDGFR', 'KIT'],\n    'Penfluridol': ['Dopamine receptor D2'],\n    'BMS-536924': ['IGF1R'],\n    'Perhexiline': [],\n    'BI-D1870': ['PDK1'],\n    'FK 866': ['NAMPT'],\n    'Mubritinib (TAK 165)': ['EGFR', 'HER2'],\n    'Doxorubicin': ['Topoisomerase II'],\n    'Pomalidomide': ['Cereblon'],\n    'Colforsin': ['Adenylyl cyclase'],\n    'Phenylbutazone': [],\n    'Protriptyline': [],\n    'Buspirone': ['5-HT1A receptor'],\n    'Clomipramine': [],\n    'Alogliptin': ['DPP4'],\n    'Nefazodone': ['Serotonin receptor'],\n    'ABT737': ['BCL2', 'BCL-XL', 'BCL-W'],\n    'Dactolisib': ['PIK3CA', 'PIK3CB', 'PIK3CD', 'PIK3CG', 'MTOR'],\n    'Nilotinib': ['ABL1', 'KIT', 'PDGFRA', 'BCR-ABL'],\n    'Buspirone': ['5-HT1A receptor'],\n    'Clomipramine': [],\n    'Alogliptin': ['DPP4'],\n    'Nefazodone': ['Serotonin receptor'],\n    'ABT737': ['BCL2', 'BCL-XL', 'BCL-W'],\n    'Dactolisib': ['PIK3CA', 'PIK3CB', 'PIK3CD', 'PIK3CG', 'MTOR'],\n    'Nilotinib': ['ABL1', 'KIT', 'PDGFRA', 'BCR-ABL'],\n    'Defactinib': ['FAK'],\n    'PF-04691502': ['FAK'],\n    'GLPG0634': ['JAK1', 'JAK2'],\n    'Sgc-cbp30': ['BRD4'],\n    'BX 912': ['PDK1'],\n    'SCH-58261': ['Adenosine receptor'],\n    'Ruxolitinib': ['JAK1', 'JAK2'],\n    'BAY 87-2243': [],\n    'O-Demethylated Adapalene': [],\n    'YK 4-279': [],\n    'Ganetespib (STA-9090)': [],\n    'SLx-2119': [],\n    'Oprozomib (ONX 0912)': ['Proteasome'],\n    'Desloratadine': ['Histamine receptor'],\n    'Pitavastatin Calcium': ['HMGCR'],\n    'TR-14035': [],\n    'AT13387': ['HSP90'],\n    'CHIR-99021': [],\n    'RG7090': ['ALK'],\n    'AMD-070 (hydrochloride)': [],\n    'BMS-265246': [],\n    'Tipifarnib': ['HRAS', 'KRAS', 'NRAS'],\n    'Imatinib': ['ABL1', 'KIT', 'PDGFRA'],\n    'Topotecan': ['TOP1'],\n    'Clemastine': ['H1F0', 'H1FX'],\n    '5-(9-Isopropyl-8-methyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine': [],\n    'CGM-097': [],\n    'TGX 221': ['PIK3CA'],\n    'Azacitidine': ['DNMT1'],\n    'Atorvastatin': ['HMGCR'],\n    'Riociguat': ['Guanylate cyclase'],\n}\n\n```\n\nPossible additions:\n\n (Crizotinib + ROS1, Vandetanib + RET, Cabozantinib + AXL, VEGFR2, FLT3, c-KIT, Ceritinib + ROS1, IGF-1R, FAK, ACK1/TNK2).",
    "2449997": "i think that these databases should give API access to get the targets directly Python (or other languages). haven't checked though"
  },
  "source": "meta"
}