Cool, I'll add some more papers:
\nI do not have domain expertise on single cell technologies and as an engineer/data scientist, my instinct is to refrain from throwing sophisticated predictive models on data that I do not know much about. My impression is that, the process to central dogma dna-rna-protein is continuous and if i remember my systems biology right, there is also a gene regulatory network where some of these proteins affect the expression of the genes. So the network of events is complex. I am very curious about possible spatio-temporal sequencing efforts of all these components simultaneously. Does anybody know where to begin looking into these?
", "rawMarkdown": "I do not have domain expertise on single cell technologies and as an engineer/data scientist, my instinct is to refrain from throwing sophisticated predictive models on data that I do not know much about. My impression is that, the process to central dogma dna-rna-protein is continuous and if i remember my systems biology right, there is also a gene regulatory network where some of these proteins affect the expression of the genes. So the network of events is complex. I am very curious about possible spatio-temporal sequencing efforts of all these components simultaneously. Does anybody know where to begin looking into these?", "votes": null } ], "comments": [ { "id": 1901038, "author_name": "zambonimarco", "author_url": "", "post_date": "08/16/2022 12:41:06", "content": "Cool, I'll add some more papers:
\nI do not have domain expertise on single cell technologies and as an engineer/data scientist, my instinct is to refrain from throwing sophisticated predictive models on data that I do not know much about. My impression is that, the process to central dogma dna-rna-protein is continuous and if i remember my systems biology right, there is also a gene regulatory network where some of these proteins affect the expression of the genes. So the network of events is complex. I am very curious about possible spatio-temporal sequencing efforts of all these components simultaneously. Does anybody know where to begin looking into these?
", "votes": null, "replies": [] } ], "raw_markdown_by_id": { "1900719": "## Research Papers on Multimodal Single-Cell Integration\n\n- [Integrated analysis of multimodal single-cell data](https://www.sciencedirect.com/science/article/pii/S0092867421005833)\n- [New horizons in the stormy sea of multimodal single-cell data integration](https://www.sciencedirect.com/science/article/abs/pii/S1097276521010741)\n- [Computational principles and challenges in single-cell data integration](https://www.nature.com/articles/s41587-021-00895-7)\n- [Diagonal integration of multimodal single-cell data: potential pitfalls and paths forward](https://www.nature.com/articles/s41467-022-31104-x)\n- [Bi-order multimodal integration of single-cell data](https://genomebiology.biomedcentral.com/articles/10.1186/s13059-022-02679-x)\n- [Multimodal single-cell chromatin analysis with Signac](https://www.biorxiv.org/content/10.1101/2020.11.09.373613v1.abstract)\n- [Multimodal single-cell approaches shed light on T cell heterogeneity](https://www.sciencedirect.com/science/article/abs/pii/S0952791519300469)\n- [Cobolt: integrative analysis of multimodal single-cell sequencing data](https://genomebiology.biomedcentral.com/articles/10.1186/s13059-021-02556-z)", "1901038": "Cool, I'll add some more papers:\n- [Multigrate: single-cell multi-omic data integration](https://icml-compbio.github.io/2021/papers/WCBICML2021_paper_44.pdf)\n- [Joint probabilistic modeling of single-cell multi-omic data with\ntotalVI](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954949/pdf/nihms-1656427.pdf)\n- [scAI: an unsupervised approach for the\nintegrative analysis of parallel single-cell\ntranscriptomic and epigenomic profiles](https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-020-1932-8.pdf)\n- [Multi-Omics Factor Analysis—a framework for unsupervised integration of multi-omics data sets] (https://www.embopress.org/doi/full/10.15252/msb.20178124)\n- [Multi-domain translation between single-cell imaging and sequencing data using autoencoders](https://www.nature.com/articles/s41467-020-20249-2)\n- [Comprehensive Integration of Single-Cell Data](https://www.cell.com/cell/fulltext/S0092-8674(19)30559-8)", "1941193": "I do not have domain expertise on single cell technologies and as an engineer/data scientist, my instinct is to refrain from throwing sophisticated predictive models on data that I do not know much about. My impression is that, the process to central dogma dna-rna-protein is continuous and if i remember my systems biology right, there is also a gene regulatory network where some of these proteins affect the expression of the genes. So the network of events is complex. I am very curious about possible spatio-temporal sequencing efforts of all these components simultaneously. Does anybody know where to begin looking into these?" }, "source": "meta" }